Emergency services were called to Seven Sisters road in Finsbury Park, north London, after reports a vehicle had hit pedestrians just after midnight.
There a number of casualties being treated. It is not yet known what condition they are in, but it is believed that more than 10 have been injured, and three are in a serious condition.
A man has been arrested at the scene near a mosque.
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Officers have confirmed the van struck a number of people leaving Ramadan prayers.
Muslim Council general secretary Harun Khan said the van deliberately targeted worshippers.
He wrote: “Shocked and outraged to hear a van has intentionally run over worshippers leaving Ramadan prayers on Seven Sisters Road.”
Pictures have also circulated, purportedly of the white van involved.
Met Police have declared it a “major incident”.
The leader of Finsbury Park mosque, Mohammed Kozbar described the incident as a terrorist attack.
He said: ‘Whoever did this, he did it to hurt people and it’s a terrorist attack.
‘We call it a terrorist attack as we called it in Manchester, Westminster and London Bridge.”
Local resident, Cynthia Vanzella told Sky News: “I understood something bad had happened.
“I could see two people on the floor not moving, and people doing cardiac massage on them.”
The incident comes after three jihadis ploughed into pedestrians on London Bridge before stabbing revellers in Borough Market.
Depraved terrorist Khalid Masood also used his car to run down people on Westminster Bridge before stabbing a police officer to death.
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